Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii; however, polymyxin resistance can emerge with monotherapy. Therefore, synergistic combination therapy is a crucial strategy to reduce polymyxin resistance. Methods: This study conducted u...

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Udgivet i:Front Microbiol
Main Authors: Han, Mei-Ling, Liu, Xiaofen, Velkov, Tony, Lin, Yu-Wei, Zhu, Yan, Li, Mengyao, Yu, Heidi H., Zhou, Zhihui, Creek, Darren J., Zhang, Jing, Li, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250834/
https://ncbi.nlm.nih.gov/pubmed/30505298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02776
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