Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.

An understanding of how heterozygous loss-of-function mutations in ASD risk genes, such as TBR1, contribute to ASD remains elusive. Conditional Tbr1 deletion during late mouse gestation in cortical layer 6 neurons (Tbr1(layer6) mutants) provides novel insights into its function, including dendritic...

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Publicado no:Neuron
Main Authors: Siavash, Fazel Darbandi, Robinson Schwartz, Sarah E, Qihao, Qi, Rinaldo, Catta-Preta, Lin-Ling, Pai Emily, Mandell, Jeffrey D, Amanda, Everitt, Anna, Rubin, Krasnoff, Rebecca, A, Sol, Katzman, David, Tastad, Nord, Alex S, Jeremy, Willsey A., Bin, Chen, State, Matthew W., Sohal, Vikaas S, Rubenstein, John L. R
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250594/
https://ncbi.nlm.nih.gov/pubmed/30318412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.09.027
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