Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants

Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) mutants and constitutive heterozygotes have immature dendritic spines and reduced synaptic density. Tbr1 regulates ex...

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Publicado no:Cell Rep
Main Authors: Darbandi, Siavash Fazel, Schwartz, Sarah E. Robinson, Pai, Emily Ling-Lin, Everitt, Amanda, Turner, Marc L., Cheyette, Benjamin N.R., Willsey, A. Jeremy, State, Matthew W., Sohal, Vikaas S., Rubenstein, John L.R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473600/
https://ncbi.nlm.nih.gov/pubmed/32294447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.03.059
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