Protein Phosphatase 1–Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

BACKGROUND: Ebola virus (EBOV) infection causes severe hemorrhagic fever. EBOV transcription is controlled by host protein phosphatase 1 (PP1), which dephosphorylates VP30 protein. We previously developed 1E7-03, a compound targeting a noncatalytic site of PP1 that induced VP30 phosphorylation and i...

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Gepubliceerd in:J Infect Dis
Hoofdauteurs: Ammosova, Tatiana, Pietzsch, Colette A, Saygideğer, Yasemin, Ilatovsky, Andrey, Lin, Xionghao, Ivanov, Andrey, Kumari, Namita, Jerebtsova, Marina, Kulkarni, Amol, Petukhov, Michael, Üren, Aykut, Bukreyev, Alexander, Nekhai, Sergei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249606/
https://ncbi.nlm.nih.gov/pubmed/30169869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy422
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