Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03

We recently identified the protein phosphatase-1 - targeting compound, 1E7-03 which inhibited HIV-1 in vitro. Here, we investigated the effect of 1E7-03 on HIV-1 infection in vivo by analyzing its metabolic stability and antiviral activity of 1E7-03 and its metabolites in HIV-1 infected NSG-humanize...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lin, Xionghao, Kumari, Namita, DeMarino, Catherine, Kont, Yasemin Saygideğer, Ammosova, Tatiana, Kulkarni, Amol, Jerebtsova, Marina, Vazquez-Meves, Guelaguetza, Ivanov, Andrey, Dmytro, Kovalskyy, Üren, Aykut, Kashanchi, Fatah, Nekhai, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652740/
https://ncbi.nlm.nih.gov/pubmed/29100346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19999
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