Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals

by Lin, Xionghao, Ammosova, Tatyana, Kumari, Namita, Nekhai, Sergei
Published in Curr Pharm Des (2017)

Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

by Basant, Nikita, Lin, Xionghao, Reid, Terry-Elinor R., Karla, Pradeep K., Wang, Xiang S.
Published in Comb Chem High Throughput Screen (2015)

Urinary Orosomucoid is Associated with Progressive Chronic Kidney Disease Stage in Patients with Sickle Cell Anemia

by Jerebtsova, Marina, Saraf, Santosh L., Soni, Simran, Afangbedji, Nowah, Lin, Xionghao, Raslan, Rasha, Gordeuk, Victor R., Nekhai, Sergei
Published in Am J Hematol (2018)

Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation

by Carey, Brian D., Ammosova, Tatiana, Pinkham, Chelsea, Lin, Xionghao, Zhou, Weidong, Liotta, Lance A., Nekhai, Sergei, Kehn-Hall, Kylene
Published in J Virol (2018)

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

by Kumari, Namita, Kulkarni, Amol A, Lin, Xionghao, McLean, Charlee, Ammosova, Tatiana, Ivanov, Andrey, Hipolito, Maria, Nekhai, Sergei, Nwulia, Evaristus
Published in Drug Des Devel Ther (2015)

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

by Kumari, Namita, Ammosova, Tatiana, Diaz, Sharmin, Lin, Xionghao, Niu, Xiaomei, Ivanov, Andrey, Jerebtsova, Marina, Dhawan, Subhash, Oneal, Patricia, Nekhai, Sergei
Published in Blood Adv (2016)

Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription

by Tigabu, Bersabeh, Ramanathan, Palaniappan, Ivanov, Andrey, Lin, Xionghao, Ilinykh, Philipp A., Parry, Christian S., Freiberg, Alexander N., Nekhai, Sergei, Bukreyev, Alexander
Published in J Virol (2018)

Phenyl-1-Pyridin-2yl-Ethanone-Based Iron Chelators Increase IκB-α Expression, Modulate CDK2 and CDK9 Activities, and Inhibit HIV-1 Transcription

by Kumari, Namita, Iordanskiy, Sergey, Kovalskyy, Dmytro, Breuer, Denitra, Niu, Xiaomei, Lin, Xionghao, Xu, Min, Gavrilenko, Konstantin, Kashanchi, Fatah, Dhawan, Subhash, Nekhai, Sergei
Published in Antimicrob Agents Chemother (2014)

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

by Ivanov, Andrey, Lin, Xionghao, Ammosova, Tatiana, Ilatovskiy, Andrey V., Kumari, Namita, Lassiter, Hatajai, Afangbedji, Nowah, Niu, Xiaomei, Petukhov, Michael G., Nekhai, Sergei
Published in Retrovirology (2018)

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

by Stecher, Carmen, Marinkov, Sanja, Mayr-Harting, Lucia, Katic, Ana, Kastner, Marie-Theres, Rieder-Rommer, Franz J. J., Lin, Xionghao, Nekhai, Sergei, Steininger, Christoph
Published in Front Microbiol (2021)

Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound

by Smith, Kahli A., Lin, Xionghao, Bolshakov, Oleg, Griffin, James, Niu, Xiaomei, Kovalskyy, Dmytro, Ivanov, Andrey, Jerebtsova, Marina, Taylor, Robert E., Akala, Emmanuel, Nekhai, Sergei
Published in Sci Pharm (2015)

Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription

by Ivanov, Andrey, Ramanathan, Palaniappan, Parry, Christian, Ilinykh, Philipp A., Lin, Xionghao, Petukhov, Michael, Obukhov, Yuri, Ammosova, Tatiana, Amarasinghe, Gaya K., Bukreyev, Alexander, Nekhai, Sergei
Published in Cell Mol Life Sci (2019)

Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis

by Jerebtsova, Marina, Saraf, Santosh L., Lin, Xionghao, Lee, Gillian, Adjei, Elena Afia, Kumari, Namita, Afangbedji, Nowah, Raslan, Rasha, McLean, Charlee, Gordeuk, Victor R., Nekhai, Sergei
Published in Am J Hematol (2017)

Protein Phosphatase 1–Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

by Ammosova, Tatiana, Pietzsch, Colette A, Saygideğer, Yasemin, Ilatovsky, Andrey, Lin, Xionghao, Ivanov, Andrey, Kumari, Namita, Jerebtsova, Marina, Kulkarni, Amol, Petukhov, Michael, Üren, Aykut, Bukreyev, Alexander, Nekhai, Sergei
Published in J Infect Dis (2018)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

by Lin, Xionghao, Ammosova, Tatiana, Choy, Meng S., Pietzsch, Colette A., Ivanov, Andrey, Ahmad, Asrar, Saygideğer, Yasemin, Kumari, Namita, Kovalskyy, Dmytro, Üren, Aykut, Peti, Wolfgang, Bukreyev, Alexander, Nekhai, Sergei
Published in Front Microbiol (2019)

Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV-1 Inhibition

by Lin, Xionghao, Sajith, Ayyiliath M, Wang, Songping, Kumari, Namita, Choy, Meng S, Ahmad, Asrar, Cadet, Dana R., Gu, Xinbin, Ivanov, Andrey I., Peti, Wolfgang, Kulkarni, Amol, Nekhai, Sergei
Published in ACS Infect Dis (2020)

Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03

by Lin, Xionghao, Kumari, Namita, DeMarino, Catherine, Kont, Yasemin Saygideğer, Ammosova, Tatiana, Kulkarni, Amol, Jerebtsova, Marina, Vazquez-Meves, Guelaguetza, Ivanov, Andrey, Dmytro, Kovalskyy, Üren, Aykut, Kashanchi, Fatah, Nekhai, Sergei
Published in Oncotarget (2017)