Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies

Screening of monoclonal antibodies against ebolaviruses requires small-animal models. Wild-type mice require adaptation of ebolaviruses, whereas immunodeficient mice are still resistant to nonadapted Bundibugyo ebolavirus. Swapping of Ebola virus glycoprotein with that from Bundibugyo virus resulted...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Ilinykh, Philipp A, Graber, Jessica, Kuzmina, Natalia A, Huang, Kai, Ksiazek, Thomas G, Crowe, James E, Bukreyev, Alexander
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Supplement Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249583/
https://ncbi.nlm.nih.gov/pubmed/30060231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy423
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