Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests

Testing for association between a set of genetic markers and a phenotype is a fundamental task in genetic studies. Standard approaches for heritability and set testing strongly rely on parametric models that make specific assumptions regarding phenotypic variability. Here, we show that resulting p-v...

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Pubblicato in:Nat Commun
Autori principali: Schweiger, Regev, Fisher, Eyal, Weissbrod, Omer, Rahmani, Elior, Müller-Nurasyid, Martina, Kunze, Sonja, Gieger, Christian, Waldenberger, Melanie, Rosset, Saharon, Halperin, Eran
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249264/
https://ncbi.nlm.nih.gov/pubmed/30464216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07276-w
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