Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice

Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains u...

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Udgivet i:Exp Mol Med
Main Authors: Jin, Haiming, Zhang, Zengjie, Wang, Chengui, Tang, Qian, Wang, Jianle, Bai, Xueqin, Wang, Qingqing, Nisar, Majid, Tian, Naifeng, Wang, Quan, Mao, Cong, Zhang, Xiaolei, Wang, Xiangyang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249246/
https://ncbi.nlm.nih.gov/pubmed/30459300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0177-z
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