A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs

Structural interactions that enable electron transfer to cytochrome-P450 (CYP450) from its redox partner CYP450-reductase (CPR) are a vital prerequisite for its catalytic mechanism. Here, we report the first structural model for the membrane-bound functional complex to reveal interactions between th...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Prade, Elke, Mahajan, Mukesh, Im, Sang-Choul, Zhang, Meng, Gentry, Katherine A., Anantharamaiah, G.M., Waskell, Lucy, Ramamoorthy, Ayyalusamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248338/
https://ncbi.nlm.nih.gov/pubmed/29722926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802210
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