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Substrate Mediated Redox Partner Selectivity of Cytochrome P450
Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b(5)) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism f...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980791/ https://ncbi.nlm.nih.gov/pubmed/29781479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc02525h |
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