Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from the GTEx Project and genome-wide association study (GWAS) data. About 60% of known trait-associated loci are in linkage disequilibrium with a cis-eQTL, over half of which were not found in previous large-sca...

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Published in:Nat Genet
Main Authors: Gamazon, Eric R., Segrè, Ayellet V., van de Bunt, Martijn, Wen, Xiaoquan, Xi, Hualin S., Hormozdiari, Farhad, Ongen, Halit, Konkashbaev, Anuar, Derks, Eske M., Aguet, François, Quan, Jie, Nicolae, Dan L., Eskin, Eleazar, Kellis, Manolis, Getz, Gad, McCarthy, Mark I., Dermitzakis, Emmanouil T., Cox, Nancy J., Ardlie, Kristin G.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248311/
https://ncbi.nlm.nih.gov/pubmed/29955180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0154-4
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