Integrated genomic analysis of Hürthle cell cancer reveals oncogenic drivers, recurrent mitochondrial mutations, and unique chromosomal landscapes

The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here, we describe a comprehensive genomic characterization of 56 primary HCC tumors that span the spectrum of tumor behavior. We elucidate the mutational profile and driver mutations and show that they exhibit a wide ra...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Ganly, Ian, Makarov, Vladimir, Deraje, Shyamprasad, Dong, YiYu, Reznik, Ed, Seshan, Venkatraman, Nanjangud, Gouri, Eng, Stephanie, Bose, Promita, Kuo, Fengshen, Morris, Luc G. T., Landa, Inigo, Albornoz, Pedro Blecua Carrillo, Riaz, Nadeem, Nikiforov, Yuri E., Patel, Kepal, Umbricht, Christopher, Zeiger, Martha, Kebebew, Electron, Sherman, Eric, Ghossein, Ronald, Fagin, James A., Chan, Timothy A
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247912/
https://ncbi.nlm.nih.gov/pubmed/30107176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.07.002
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