Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8–mediated cell death. Here, using Yersinia pseudotuberculosis...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sarhan, Joseph, Liu, Beiyun C., Muendlein, Hayley I., Li, Peng, Nilson, Rachael, Tang, Amy Y., Rongvaux, Anthony, Bunnell, Stephen C., Shao, Feng, Green, Douglas R., Poltorak, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243247/
https://ncbi.nlm.nih.gov/pubmed/30381458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809548115
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