Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin

The Clostridium botulinum C2 toxin is an exotoxin causing severe enterotoxic symptoms. The C2 toxin consists of the binding/translocation component C2II, and the enzymatic active component C2I. After proteolytic activation, C2IIa forms heptamers that bind C2I. The C2IIa/C2I complex is taken up into...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ernst, Katharina, Kling, Carolin, Landenberger, Marc, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243138/
https://ncbi.nlm.nih.gov/pubmed/30483129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01287
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