A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

Hsp70 family proteins are folding helper proteins involved in a wide variety of cellular pathways. Members of this family interact with key factors in signal transduction, transcription, cell-cycle control, and stress response. Here, we developed the first Hsp70 low molecular weight inhibitor specif...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Ernst, Katharina, Liebscher, Markus, Mathea, Sebastian, Granzhan, Anton, Schmid, Johannes, Popoff, Michel R., Ihmels, Heiko, Barth, Holger, Schiene-Fischer, Cordelia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738285/
https://ncbi.nlm.nih.gov/pubmed/26839186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20301
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