Membrane Translocation of Binary Actin-ADP-Ribosylating Toxins from Clostridium difficile and Clostridium perfringens Is Facilitated by Cyclophilin A and Hsp90

Some hypervirulent strains of Clostridium difficile produce the binary actin-ADP-ribosylating toxin C. difficile transferase (CDT) in addition to Rho-glucosylating toxins A and B. It has been suggested that the presence of CDT increases the severity of C. difficile-associated diseases, including pse...

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Detalhes bibliográficos
Main Authors: Kaiser, Eva, Kroll, Claudia, Ernst, Katharina, Schwan, Carsten, Popoff, Michel, Fischer, Gunter, Buchner, Johannes, Aktories, Klaus, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187244/
https://ncbi.nlm.nih.gov/pubmed/21768281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05372-11
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