IFNα induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

AIM/HYPOTHESIS: IFNα, a cytokine expressed in human islets from type 1 diabetes patients, plays a key role in the pathogenesis of diabetes by up-regulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. We...

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Publié dans:Diabetologia
Auteurs principaux: de Brachène, Alexandra Coomans, Dos Santos, Reinaldo Sousa, Marroqui, Laura, Colli, Maikel L., Marselli, Lorella, Mirmira, Raghavendra G., Marchetti, Piero, Eizirik, Decio L.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6241216/
https://ncbi.nlm.nih.gov/pubmed/29305625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4536-4
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