Radiation followed by OX40 stimulation drives local and abscopal antitumor effects in an anti-PD1-resistant lung tumor model

PURPOSE: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system have increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibitors such as anti-PD1. The majority of patients eit...

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Pubblicato in:Clin Cancer Res
Autori principali: Niknam, Sharareh, Barsoumian, Hampartsoum B., Schoenhals, Jonathan E., Jackson, Heather L., Yanamandra, Niranjan, Caetano, Mauricio S., Li, Ailin, Younes, Ahmed I., Cadena, Alexandra, Cushman, Taylor R., Chang, Joe Y., Nguyen, Quynh N., Gomez, Daniel R., Diab, Adi, Heymach, John V., Hwu, Patrick, Cortez, Maria Angelica, Welsh, James W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239963/
https://ncbi.nlm.nih.gov/pubmed/29784675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3279
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