Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells

Indoleamine 2,3-dioxygenase 1 (IDO1), involved in the catabolism of tryptophan (Trp) to kynurenine (Kyn) is an important regulator of tumor-mediated immunosuppression implicated in resistance to anti-PD1 immunotherapy. We investigated the role of IDO1 in an anti-PD1-resistant lung cancer model (344S...

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Опубликовано в: :Cancer Lett
Главные авторы: Li, Ailin, Barsoumian, Hampartsoum B., Schoenhals, Jonathan E., Cushman, Taylor R., Caetano, Mauricio S., Wang, Xiaohong, Valdecanas, David R., Niknam, Sharareh, Younes, Ahmed I., Li, Guang, Woodward, Wendy A., Cortez, Maria Angelica, Welsh, James W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027590/
https://ncbi.nlm.nih.gov/pubmed/29746927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.05.005
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