Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Schoenhals, Jonathan E., Cushman, Taylor R., Barsoumian, Hampartsoum B., Li, Ailin, Cadena, Alexandra P., Niknam, Sharareh, Younes, Ahmed I., Caetano, Mauricio da Silva, Cortez, Maria Angelica, Welsh, James W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158365/
https://ncbi.nlm.nih.gov/pubmed/30294332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02170
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