Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-...

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發表在:Front Immunol
Main Authors: Schoenhals, Jonathan E., Cushman, Taylor R., Barsoumian, Hampartsoum B., Li, Ailin, Cadena, Alexandra P., Niknam, Sharareh, Younes, Ahmed I., Caetano, Mauricio da Silva, Cortez, Maria Angelica, Welsh, James W.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158365/
https://ncbi.nlm.nih.gov/pubmed/30294332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02170
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