Radiation followed by OX40 stimulation drives local and abscopal antitumor effects in an anti-PD1-resistant lung tumor model

PURPOSE: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system have increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibitors such as anti-PD1. The majority of patients eit...

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Publicat a:Clin Cancer Res
Autors principals: Niknam, Sharareh, Barsoumian, Hampartsoum B., Schoenhals, Jonathan E., Jackson, Heather L., Yanamandra, Niranjan, Caetano, Mauricio S., Li, Ailin, Younes, Ahmed I., Cadena, Alexandra, Cushman, Taylor R., Chang, Joe Y., Nguyen, Quynh N., Gomez, Daniel R., Diab, Adi, Heymach, John V., Hwu, Patrick, Cortez, Maria Angelica, Welsh, James W.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239963/
https://ncbi.nlm.nih.gov/pubmed/29784675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3279
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