MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity

MERTK is ectopically expressed and promotes survival in acute lymphoblastic leukemia (ALL) cells and is thus a potential therapeutic target. Here we demonstrate both direct therapeutic effects of MERTK inhibition on leukemia cells and induction of anti-leukemia immunity via suppression of the coinhi...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Lee-Sherick, Alisa B., Jacobsen, Kristen M., Henry, Curtis J., Huey, Madeline G., Parker, Rebecca E., Page, Lauren S., Hill, Amanda A., Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Jordan, Craig T., DeRyckere, Deborah, Graham, Douglas K.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238750/
https://ncbi.nlm.nih.gov/pubmed/30385715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97941
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