MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity

MERTK is ectopically expressed and promotes survival in acute lymphoblastic leukemia (ALL) cells and is thus a potential therapeutic target. Here we demonstrate both direct therapeutic effects of MERTK inhibition on leukemia cells and induction of anti-leukemia immunity via suppression of the coinhi...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lee-Sherick, Alisa B., Jacobsen, Kristen M., Henry, Curtis J., Huey, Madeline G., Parker, Rebecca E., Page, Lauren S., Hill, Amanda A., Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Jordan, Craig T., DeRyckere, Deborah, Graham, Douglas K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238750/
https://ncbi.nlm.nih.gov/pubmed/30385715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97941
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