MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

BACKGROUND: MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM). Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cells, implicating MERTK as a potential t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sufit, Alexandra, Lee-Sherick, Alisa B., DeRyckere, Deborah, Rupji, Manali, Dwivedi, Bhakti, Varella-Garcia, Marileila, Pierce, Angela M., Kowalski, Jeanne, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Keating, Amy K., Graham, Douglas K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081168/
https://ncbi.nlm.nih.gov/pubmed/27783662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165107
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