RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif

TRIM5α is a cytoplasmic restriction factor that blocks post-entry retroviral infection. Evidence suggests that its antiviral activity can be regulated by SUMO, but how this is achieved remains unknown. Here, we show that TRIM5α forms a complex with RanGAP1, Ubc9, and RanBP2 at the nuclear pore, and...

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Dades bibliogràfiques
Publicat a:Commun Biol
Autors principals: Maarifi, Ghizlane, Fernandez, Juliette, Portilho, Débora M., Boulay, Aude, Dutrieux, Jacques, Oddos, Stéphane, Butler-Browne, Gillian, Nisole, Sébastien, Arhel, Nathalie J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237768/
https://ncbi.nlm.nih.gov/pubmed/30456314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0198-0
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