PLK1 targets CtIP to promote microhomology-mediated end joining

Proper DNA double-strand break (DSB) repair is essential for maintaining genome integrity. Microhomology-mediated end joining (MMEJ) is an error-prone repair mechanism, which introduces mutations at break sites and contributes to chromosomal translocations and telomere fusions, thus driving carcinog...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Wang, Hailong, Qiu, Zhiyu, Liu, Bo, Wu, Yan, Ren, Jianping, Liu, Yaqing, Zhao, Yuqin, Wang, Ya, Hao, Shuailin, Li, Zheng, Peng, Bin, Xu, Xingzhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237753/
https://ncbi.nlm.nih.gov/pubmed/30202980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky810
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