I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

DNA polymerase β (pol β) fills single nucleotide gaps in DNA during base excision repair and non-homologous end-joining. Pol β must select the correct nucleotide from among a pool of four nucleotides with similar structures and properties in order to maintain genomic stability during DNA repair. Her...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Liptak, Cary, Mahmoud, Mariam M, Eckenroth, Brian E, Moreno, Marcus V, East, Kyle, Alnajjar, Khadijeh S, Huang, Ji, Towle-Weicksel, Jamie B, Doublié, Sylvie, Loria, J Patrick, Sweasy, Joann B
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237750/
https://ncbi.nlm.nih.gov/pubmed/30239932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky825
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