Newly Synthesized Polycystin 1 Takes Different Trafficking Pathways to the Apical and Ciliary Membranes

Mutations in the genes encoding polycystin 1 (PC1) and polycysin 2 (PC2) cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). These transmembrane proteins co-localize in the primary cilia of renal epithelial cells, where they may participate in sensory processes. PC1 is also found in the apic...

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Bibliografische gegevens
Gepubliceerd in:Traffic
Hoofdauteurs: Gilder, Allison L., Chapin, Hannah C., Padovano, Valeria, Hueschen, Christina L., Rajendran, Vanathy, Caplan, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237641/
https://ncbi.nlm.nih.gov/pubmed/30125442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12612
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