Protein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder causing renal failure. Mutations of polycystic kidney disease 1 (PKD1) account for most ADPKD cases. Defective ciliary localization of polycystin-1 (PC1), a large integral membrane protein encoded by PKD1, under...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Luo, Chong, Wu, Maoqing, Su, Xuefeng, Yu, Fangyan, Brautigan, David L., Chen, Jianghua, Zhou, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704455/
https://ncbi.nlm.nih.gov/pubmed/31157564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900338R
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