Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil

Relapse‐specific mutations in phosphoribosyl pyrophosphate synthetase 1 (PRPS1), a rate‐limiting purine biosynthesis enzyme, confer significant drug resistances to combination chemotherapy in acute lymphoblastic leukemia (ALL). It is of particular interest to identify drugs to overcome these resista...

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Detaylı Bibliyografya
Yayımlandı:J Cell Mol Med
Asıl Yazarlar: Wang, Dan, Chen, Yao, Fang, Houshun, Zheng, Liang, Li, Ying, Yang, Fan, Xu, Yan, Du, Lijuan, Zhou, Bin‐Bing S., Li, Hui
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237573/
https://ncbi.nlm.nih.gov/pubmed/30255549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13907
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