Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil

Relapse‐specific mutations in phosphoribosyl pyrophosphate synthetase 1 (PRPS1), a rate‐limiting purine biosynthesis enzyme, confer significant drug resistances to combination chemotherapy in acute lymphoblastic leukemia (ALL). It is of particular interest to identify drugs to overcome these resista...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Cell Mol Med
मुख्य लेखकों: Wang, Dan, Chen, Yao, Fang, Houshun, Zheng, Liang, Li, Ying, Yang, Fan, Xu, Yan, Du, Lijuan, Zhou, Bin‐Bing S., Li, Hui
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2018
विषय:
Original Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237573/
https://ncbi.nlm.nih.gov/pubmed/30255549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13907
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