Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3(+)RORγt(+) Regulatory T Cells

Foxp3(+) regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood. Here we show that the transcription factor Blimp-1 is a crucial regulator of the Foxp3(+)RORγt(+) Treg subset. The intrinsic expression of...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Ogawa, Chihiro, Bankoti, Rashmi, Nguyen, Truc, Hassanzadeh-Kiabi, Nargess, Nadeau, Samantha, Porritt, Rebecca A., Couse, Michael, Fan, Xuemo, Dhall, Deepti, Eberl, Gerald, Ohnmacht, Caspar, Martins, Gislâine A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237548/
https://ncbi.nlm.nih.gov/pubmed/30282028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.016
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