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4-1BB enhancement of CAR T function requires NF-κB and TRAFs
Chimeric antigen receptors (CARs) have an antigen-binding domain fused to transmembrane, costimulatory, and CD3ζ domains. Two CARs with regulatory approval include a CD28 or 4-1BB costimulatory domain. While both CARs achieve similar clinical outcomes, biologic differences have become apparent but n...
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| 發表在: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237232/ https://ncbi.nlm.nih.gov/pubmed/30232281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121322 |
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