4-1BB enhancement of CAR T function requires NF-κB and TRAFs

Chimeric antigen receptors (CARs) have an antigen-binding domain fused to transmembrane, costimulatory, and CD3ζ domains. Two CARs with regulatory approval include a CD28 or 4-1BB costimulatory domain. While both CARs achieve similar clinical outcomes, biologic differences have become apparent but n...

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Pubblicato in:JCI Insight
Autori principali: Li, Gongbo, Boucher, Justin C., Kotani, Hiroshi, Park, Kyungho, Zhang, Yongliang, Shrestha, Bishwas, Wang, Xuefeng, Guan, Lawrence, Beatty, Nolan, Abate-Daga, Daniel, Davila, Marco L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237232/
https://ncbi.nlm.nih.gov/pubmed/30232281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121322
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