PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

The germinal center (GC) reaction plays an important role in generating humoral immunity and is believed to give rise to most B-cell lymphomas. GC entry and exit are tightly regulated processes, controlled by the actions of transcription factors such as BCL6. Herein, we demonstrate that protein argi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Lu, Xiaoqing, Fernando, Tharu M., Lossos, Chen, Yusufova, Nevin, Liu, Fan, Fontán, Lorena, Durant, Matthew, Geng, Huimin, Melnick, Jacob, Luo, Yuan, Vega, Francisco, Moy, Vincent, Inghirami, Giorgio, Nimer, Stephen, Melnick, Ari M., Lossos, Izidore S.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236466/
https://ncbi.nlm.nih.gov/pubmed/30082494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-831438
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