PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

The germinal center (GC) reaction plays an important role in generating humoral immunity and is believed to give rise to most B-cell lymphomas. GC entry and exit are tightly regulated processes, controlled by the actions of transcription factors such as BCL6. Herein, we demonstrate that protein argi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Lu, Xiaoqing, Fernando, Tharu M., Lossos, Chen, Yusufova, Nevin, Liu, Fan, Fontán, Lorena, Durant, Matthew, Geng, Huimin, Melnick, Jacob, Luo, Yuan, Vega, Francisco, Moy, Vincent, Inghirami, Giorgio, Nimer, Stephen, Melnick, Ari M., Lossos, Izidore S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236466/
https://ncbi.nlm.nih.gov/pubmed/30082494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-831438
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