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Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications ‡

Synthesis of the title compound,1-(2'-O-methyl-ß-D-ribofuranosyl)-1H-imidazo-[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in four steps, starting from methyl 1-(ß-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 was protected wit...

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書目詳細資料
發表在:Molecules
Main Authors: Chen, Huan-Ming, Hosmane, Ramachandra S.
格式: Artigo
語言:Inglês
出版: MDPI 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236401/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/60300203
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