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Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observa...
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| Pubblicato in: | Sci Adv |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Association for the Advancement of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6235539/ https://ncbi.nlm.nih.gov/pubmed/30443600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau9859 |
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