First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1

BACKGROUND: Live, attenuated viral vectors that express HIV-1 antigens are being investigated as an approach to generating durable immune responses against HIV-1 in humans. We recently developed a replication-competent, highly attenuated Ad26 vector that expresses mosaic HIV-1 Env (rcAd26.MOS1.HIV-E...

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Pubblicato in:PLoS One
Autori principali: Stephenson, Kathryn E., Keefer, Michael C., Bunce, Catherine A., Frances, Doreen, Abbink, Peter, Maxfield, Lori F., Neubauer, George H., Nkolola, Joseph, Peter, Lauren, Lane, Christopher, Park, Harriet, Verlinde, Carl, Lombardo, Angela, Yallop, Christopher, Havenga, Menzo, Fast, Patricia, Treanor, John, Barouch, Dan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235250/
https://ncbi.nlm.nih.gov/pubmed/30427829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205139
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