First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1

BACKGROUND: Live, attenuated viral vectors that express HIV-1 antigens are being investigated as an approach to generating durable immune responses against HIV-1 in humans. We recently developed a replication-competent, highly attenuated Ad26 vector that expresses mosaic HIV-1 Env (rcAd26.MOS1.HIV-E...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Stephenson, Kathryn E., Keefer, Michael C., Bunce, Catherine A., Frances, Doreen, Abbink, Peter, Maxfield, Lori F., Neubauer, George H., Nkolola, Joseph, Peter, Lauren, Lane, Christopher, Park, Harriet, Verlinde, Carl, Lombardo, Angela, Yallop, Christopher, Havenga, Menzo, Fast, Patricia, Treanor, John, Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235250/
https://ncbi.nlm.nih.gov/pubmed/30427829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205139
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