E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

BACKGROUND: Expression of E2F transcription factor 2 (E2F2), a transcription factor related to the cell cycle, is abnormally high in rheumatoid arthritis synovial fibroblasts (RASFs). Deregulated expression of E2F2 leads to abnormal production of proinflammatory cytokines, such as interleukin (IL)-1...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Wang, Shiguan, Wang, Lin, Wu, Changshun, Sun, Shui, Pan, Ji-hong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235203/
https://ncbi.nlm.nih.gov/pubmed/30286793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1713-x
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