Pig Liver Esterase Hydrolysis of 2-Arachidonoglycerol Exacerbates PRRSV-Induced Inflammation via PI3K-Akt-NF-κB Pathway

Inflammation is essential for host defense but requires strict regulation to prevent immunopathology. This study reveals how pig liver esterase (PLE) in alveolar macrophages (PAMs) modulates PRRSV-induced inflammation through endocannabinoid metabolism. We identified PLE6 as the dominant hydrolytica...

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Detalhes bibliográficos

Principais autores:	Yuelin Fu, Huiwen Zhu, Qiling Xiao, Qi Chen, Qiongqiong Zhou, Xiliang Wang, Deshi Shi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-08-01
coleção:	Cells
Assuntos:	pig liver esterase porcine alveolar macrophages inflammation Porcine Reproductive and Respiratory Syndrome Virus 2-arachidonoglycerol
Acesso em linha:	https://www.mdpi.com/2073-4409/14/16/1227
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