The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State

G protein-coupled receptors can exist as dimers and higher-order oligomers in biological membranes. The specific oligomeric assembly of these receptors is believed to play a major role in their function, and the disruption of native oligomers has been implicated in specific human pathologies. Comput...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Mallory, D. Paul, Gutierrez, Elizabeth, Pinkevitch, Margaret, Klinginsmith, Christie, Comar, William D., Roushar, Francis J., Schlebach, Jonathan P., Smith, Adam W., Jastrzebska, Beata
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234845/
https://ncbi.nlm.nih.gov/pubmed/30085663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00403
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