Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning

Membrane proteins must balance the sequence constraints associated with folding and function against the hydrophobicity required for solvation within the bilayer. We recently found the expression and maturation of rhodopsin are limited by the hydrophobicity of its seventh transmembrane domain (TM7),...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Penn, Wesley D., McKee, Andrew G., Kuntz, Charles P., Woods, Hope, Nash, Veronica, Gruenhagen, Timothy C., Roushar, Francis J., Chandak, Mahesh, Hemmerich, Chris, Rusch, Douglas B., Meiler, Jens, Schlebach, Jonathan P.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056298/
https://ncbi.nlm.nih.gov/pubmed/32181350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay7505
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