mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

N(6)-Methyladenosine (m(6)A) modification of messenger RNA (mRNA) is emerging as an important regulator of gene expression that impacts different developmental and biological processes, and altered m(6)A homeostasis is linked to cancer(1-5). m(6)A is catalyzed by METTL3 and enriched in the 3’ untran...

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Udgivet i:Nature
Main Authors: Choe, Junho, Lin, Shuibin, Zhang, Wencai, Liu, Qi, Wang, Longfei, Ramirez-Moya, Julia, Du, Peng, Kim, Wantae, Tang, Shaojun, Sliz, Piotr, Santisteban, Pilar, George, Rani E., Richards, William G., Wong, Kwok-Kin, Locker, Nicolas, Slack, Frank J., Gregory, Richard I.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234840/
https://ncbi.nlm.nih.gov/pubmed/30232453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0538-8
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