mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

N(6)-Methyladenosine (m(6)A) modification of messenger RNA (mRNA) is emerging as an important regulator of gene expression that impacts different developmental and biological processes, and altered m(6)A homeostasis is linked to cancer(1-5). m(6)A is catalyzed by METTL3 and enriched in the 3’ untran...

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Vydáno v:Nature
Hlavní autoři: Choe, Junho, Lin, Shuibin, Zhang, Wencai, Liu, Qi, Wang, Longfei, Ramirez-Moya, Julia, Du, Peng, Kim, Wantae, Tang, Shaojun, Sliz, Piotr, Santisteban, Pilar, George, Rani E., Richards, William G., Wong, Kwok-Kin, Locker, Nicolas, Slack, Frank J., Gregory, Richard I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234840/
https://ncbi.nlm.nih.gov/pubmed/30232453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0538-8
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