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mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

N(6)-Methyladenosine (m(6)A) modification of messenger RNA (mRNA) is emerging as an important regulator of gene expression that impacts different developmental and biological processes, and altered m(6)A homeostasis is linked to cancer(1-5). m(6)A is catalyzed by METTL3 and enriched in the 3’ untran...

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הוצא לאור ב:	Nature
Main Authors:	Choe, Junho, Lin, Shuibin, Zhang, Wencai, Liu, Qi, Wang, Longfei, Ramirez-Moya, Julia, Du, Peng, Kim, Wantae, Tang, Shaojun, Sliz, Piotr, Santisteban, Pilar, George, Rani E., Richards, William G., Wong, Kwok-Kin, Locker, Nicolas, Slack, Frank J., Gregory, Richard I.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2018
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6234840/ https://ncbi.nlm.nih.gov/pubmed/30232453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0538-8
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mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

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