Aberrant GSK3β nuclear localization promotes AML growth and drug resistance

Acute myeloid leukemia (AML) is a devastating disease with poor patient survival. As targetable mutations in AML are rare, novel oncogenic mechanisms are needed to define new therapeutic targets. We identified AML cells that exhibit an aberrant pool of nuclear glycogen synthase kinase 3β (GSK3β). Th...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Ignatz-Hoover, James J., Wang, Victoria, Mackowski, Nathan M., Roe, Anne J., Ghansah, Isaac K., Ueda, Masumi, Lazarus, Hillard M., de Lima, Marcos, Paietta, Elisabeth, Fernandez, Hugo, Cripe, Larry, Tallman, Martin, Wald, David N.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234355/
https://ncbi.nlm.nih.gov/pubmed/30385433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016006
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