Aberrant GSK3β nuclear localization promotes AML growth and drug resistance

Acute myeloid leukemia (AML) is a devastating disease with poor patient survival. As targetable mutations in AML are rare, novel oncogenic mechanisms are needed to define new therapeutic targets. We identified AML cells that exhibit an aberrant pool of nuclear glycogen synthase kinase 3β (GSK3β). Th...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Ignatz-Hoover, James J., Wang, Victoria, Mackowski, Nathan M., Roe, Anne J., Ghansah, Isaac K., Ueda, Masumi, Lazarus, Hillard M., de Lima, Marcos, Paietta, Elisabeth, Fernandez, Hugo, Cripe, Larry, Tallman, Martin, Wald, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234355/
https://ncbi.nlm.nih.gov/pubmed/30385433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016006
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