Aberrant GSK3β nuclear localization promotes AML growth and drug resistance

Acute myeloid leukemia (AML) is a devastating disease with poor patient survival. As targetable mutations in AML are rare, novel oncogenic mechanisms are needed to define new therapeutic targets. We identified AML cells that exhibit an aberrant pool of nuclear glycogen synthase kinase 3β (GSK3β). Th...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Ignatz-Hoover, James J., Wang, Victoria, Mackowski, Nathan M., Roe, Anne J., Ghansah, Isaac K., Ueda, Masumi, Lazarus, Hillard M., de Lima, Marcos, Paietta, Elisabeth, Fernandez, Hugo, Cripe, Larry, Tallman, Martin, Wald, David N.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234355/
https://ncbi.nlm.nih.gov/pubmed/30385433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016006
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